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It’s happened. The first children genetically engineered with the powerful DNA-editing tool called CRISPR-Cas9 have been born to a woman in China. Their altered genes will be passed to their children, and their children’s children. Join CRISPR’s co-discoverer, microbiologist Jennifer Doudna, as we explore the perils and the promise of this powerful technology. It is not the first time human ingenuity has created something capable of doing us great good and great harm. Are we up to the challenge of guiding how CRISPR will shape the future?

PARTICIPANTS: Jennifer Doudna, Jamie Metzl, William Hurlbut

MODERATOR: Guy McKhann

MORE INFO ABOUT THE PROGRAM AND
PARTICIPANTS: https://www.worldsciencefestiv....al.com/programs/cris

TOPICS
0:00 - Introduction
1:55 - Jennifer Doudna introduction
2:25 - How do we learn to use CRISPR technology wisely?
3:29 - The basics of understanding CRISPR
6:04 - Genetic engineering explainer film
7:39 - How can CRISPR help the worldwide food chain?
9:57 - Genetic disease treatment
14:25 - Improving quality of life
15:55 - Designer babies
17:55 - The gene drive
19:25 - Confronting the ethical implications of CRISPR
23:55 - Jennifer’s childhood in Hawaii
28:25 - Patents
32:08 - Importance of accuracy
32:40 - Germ cells vs somatic cells
35:58 - He Jiankui controversy
40:05 - What makes CRISPR dangerous?
43:48 - How do we enforce regulation of CRISPR use?
53:50 - The aftermath of He Jiankui’s work
1:09:25 - How do we make CRISPR technology accessible globally?
1:14:00 - How do we balance natural biology and CRISPR?
1:18:44 - How will CRISPR impact our future as a species?

PROGRAM CREDITS
- Produced by Nils Kongshaug
- Associate Produced by Emmalina Glinskis
- Music provided by APM
- Additional images and footage provided by: Getty Images, Shutterstock, Videoblocks.
- Recorded at the Simons Foundation's Gerald D. Fishbaum Auditorium

The Kavli Prize recognizes scientists for their seminal advances in astrophysics, nanoscience, and neuroscience. The series, “The Big, the Small, and the Complex,” is sponsored by The Kavli Foundation.

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Robbert Dijkgraaf, Perimeter Institute for Theoretical Physics
March 5th, 2014

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Mathematics has proven to be "unreasonably effective" in understanding nature. The fundamental laws of physics can be captured in beautiful formulae. In this lecture I want to argue for the reverse effect: Nature is an important source of inspiration for mathematics, even of the purest kind. In recent years ideas from quantum field theory, elementary particles physics and string theory have completely transformed mathematics, leading to solutions of deep problems, suggesting new invariants in geometry and topology, and, perhaps most importantly, putting modern mathematical ideas in a `natural’ context.
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visit Perimeter Institute's website to find this and other speakers

http://www.perimeterinstitute.ca/video-library

http://pirsa.org/

Where do we get our mathematical symbols from? Why is the set of integers called ℤ ? When was the equals sign first used? How about zero? Good notation tends to catch on quickly, whereas bad notation can obscure beautiful theory.

The lecture explores how the introduction of new notation has paved the way for new leaps in understanding, and considers some mathematical quirks of language, such as what the number 4 in English has in common with the number 11 in Russian.

A lecture by Sarah Hart

The transcript and downloadable versions of the lecture are available from the Gresham College website:
http://www.gresham.ac.uk/lectu....res-and-events/maths

Gresham College has been giving free public lectures since 1597. This tradition continues today with all of our five or so public lectures a week being made available for free download from our website. There are currently over 2,000 lectures free to access or download from the website.

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